June 1, 2017 @ 8:00 am – 9:00 am
Leonard Sandridge Auditorium, McKim Hall, 1st Floor
1300 Jefferson Park Ave
Charlottesville, VA 22903
William WIlson, MD

The Annual Meinhard Robinow Lecture
Pediatric Grand Rounds
8 AM Thursday,  June 1, 2017
Leonard Sandridge Auditorium (McKim Hall, 1st floor)

Speaker:  Barry Wolf, M.D., PhD.

Title: “Biotinidase Deficiency: From the Laboratory to the Patient and Back Again”

Dr. Wolf is a world-renowned medical  and biochemical geneticist, and is the  Emeritus Chair, Department of Medical Genetics, Henry Ford Hospital and Professor, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine.  In 1982,  while on the faculty of the Medical College of Virginia, Dr. Wolf discovered that the biochemical cause of late-onset multiple carboxylase deficiency was a deficiency in the activity of the enzyme, biotinidase. . In 1984, he developed a simple, inexpensive newborn screening test for the disorder and, with the cooperation of the Division of Consolidated Laboratory Services in Virginia, piloted the first biotinidase deficiency screening of newborns in the world.  Since then, this program and others have identified enzyme-deficient individuals at birth and initiated  life-long biotin treatment, which has successfully prevented the development of symptoms and has resulted in healthy and productive adults. Today, all states and many countries screen their newborns for biotinidase deficiency, which is a part of the “standard” newborn screen. .

The Meinhard Robinow Lecture was established in the 1990’s by friends and colleagues  to honor the late Dr. Robinow, who was a member of the Department of Pediatrics and Division of Genetics from 1975-1979.

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