iTHRIV Pilot Translational and Clinical Studies Program Request for Applications

iTHRIV Pilot Translational and Clinical Studies Program

Request for Applications

Application Deadline: March 15, 2019

The iTHRIV Pilot Translational and Clinical Studies (PTC) Program is a core component of the NIH-funded Clinical and Translational Sciences Award, “The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve Health.” The goal of the iTHRIV PTC Program is to help teams transition from early-stage seed grants and proof-of-concept studies to externally-funded translational research and clinical application.

The iTHRIV PTC Program is particularly interested in funding projects related to data science and those that involve collaboration across the iTHRIV partner institutions Inova, the University of Virginia, Virginia Tech and Carilion Clinic.

Proposals must involve an interdisciplinary team, and inclusion of multiple PIs or co-PIs is encouraged. Any full-time faculty member at a partner institution may serve as the contact PI for an application. All projects involving human subjects must have an approved or pending (submitted) human subjects protocol or documented exemption at the time of submission.

Evaluation Criteria and Proposal Review
iTHRIV PTC applications will be evaluated by reviewers from all three institutions and the top proposals selected for a Studio review in April/May 2019. The Studio review will include an oral presentation and discussion with a panel of reviewers with translational expertise, and is designed to help teams identify gaps and recruit additional expertise needed to successfully complete their projects. Applications will be evaluated based on the following criteria:

1. Does the project involve an innovative approach to an important clinical problem?
2. Is the project supported by appropriate preliminary data supporting the feasibility of translation to the clinic?
3. Does the project employ a team science approach and include personnel with the required expertise? Priority will be given to multi-site collaborative projects.
4. Is the project likely to lead to follow-on funding and/or translation to clinic?

Teams should submit a single PDF containing the application Coversheet, a 5-page proposal, a budget page, and NIH-style biosketches for key personnel by email to The 5-page proposal should include sections on Specific Aims, Impact, Project Team, Research Plan, Description of Team Science, Timeline, Plan for Follow-on Funding and Studies, and References.

Funding for the seed grant program is contingent upon receipt of CTSA funding for iTHRIV. Single-institution teams may request up to $25,000 of direct costs only, and multi-institution teams may request up to $50,000 of direct costs. All awards require approval from the National Institutes of Health, and funds must be expended within a single year (anticipated dates for Year 1 awards are approximately July 1, 2019 – June 30, 2020). Teams should provide an estimated budget at the time of application; formal approval by the appropriate grants offices will be requested only for those projects selected for a Studio. No carry over will be permitted.

Questions? Need help finding a partner for a project? Contact

Please access a printable copy of the RFA AND the application coversheet here:  iTHRIV_PilotStudiesRFP2019 final 020819 jhk.

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